Blar i forfatter "Schneider, Yannik Karl Heinz"

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    • Bioassay-Guided Fractionation Leads to the Detection of Cholic Acid Generated by the Rare Thalassomonas sp. 

      Pheiffer, Fazlin; Schneider, Yannik Karl Heinz; Hansen, Espen Holst; Andersen, Jeanette Hammer; Isaksson, Johan Mattias; Busche, Tobias; Rückert, Christian; Kalinowski, Jörn; van Zyl, Leonardo; Trindade, Marla (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-20)
      Bacterial symbionts of marine invertebrates are rich sources of novel, pharmaceutically relevant natural products that could become leads in combatting multidrug-resistant pathogens and treating disease. In this study, the bioactive potential of the marine invertebrate symbiont Thalassomonas actiniarum was investigated. Bioactivity screening of the strain revealed Gram-positive specific antibacterial ...

    • Four new suomilides isolated from the cyanobacterium Nostoc sp. KVJ20 and proposal of their biosynthetic origin 

      Schneider, Yannik Karl Heinz; Liaimer, Anton; Isaksson, Johan Mattias; Wilhelmsen, Oda Sofie Bye; Andersen, Jeanette Hammer; Østnes Hansen, Kine; Hansen, Espen Holst (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-20)
      The suomilide and the banyasides are highly modified and functionalized non-ribosomal peptides produced by cyanobacteria of the order Nostocales. These compound classes share several substructures, including a complex azabicyclononane core, which was previously assumed to be derived from the amino acid tyrosine. In our study we were able to isolate and determine the structures of four suomilides, ...

    • Identification of New Purpuroine Analogues from the Arctic Echinodermata Pteraster militaris That Inhibit FLT3-ITD+ AML Cell Lines 

      Ullsten-Wahlund, Sara; Petit, Guillaume; Isaksson, Johan Mattias; Hansen, Ida Kristine Østnes; Schneider, Yannik Karl Heinz; Jenssen, Marte; Li, Chun; Østnes Hansen, Kine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-13)
      Isolation of bioactive products from the marine environment is considered a very promising approach to identify new compounds that can be used for further drug development. In this work we have isolated three new compounds from the purpuroine family by mass-guided preparative HPLC; purpuroine K-M. These compounds where screened for antibacterial- and antifungal activity, antibiofilm formation and ...

    • Selective isolation of Arctic marine actinobacteria and a down-scaled fermentation and extraction strategy for identifying bioactive compounds 

      Schneider, Yannik Karl Heinz; Hagestad, Ole Christian; Li, Chun; Hansen, Espen Holst; Andersen, Jeanette Hammer (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-21)
      Actinobacteria are among the most prolific producers of bioactive secondary metabolites. In order to collect Arctic marine bacteria for the discovery of new bioactive metabolites, actinobacteria were selectively isolated during a research cruise in the Greenland Sea, Norwegian Sea and the Barents Sea. In the frame of the isolation campaign, it was investigated how different sample treatments, isolation ...